Congenital Sucrase-Isomaltase Deficiency (CSID) is similar to lactose intolerance, a well-known carbohydrate malabsorption condition, although the two conditions are treated differently. The table below compares CSID to lactose intolerance.
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Lactose Intolerance
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CSID
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Lactose intolerance is the small intestine's inability to digest lactose due to a lack of the enzyme lactase.
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CSID is the small intestine's inability to digest sucrose due to a lack of the enzyme sucrase.
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Lactose is a type of carbohydrate found in milk and other dairy products.
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Sucrose is a type of carbohydrate, commonly referred to as table sugar, and is naturally found in many fruits and vegetables. Sucrose is a common additive in many processed foods.
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Ingestion of milk sugars causes gastrointestinal symptoms similar to those in CSID.
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Ingestion of sucrose causes gastrointestinal symptoms, most commonly diarrhea, bloating, abdominal pain, or gas.
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Lactose intolerance is typically not caused by a genetic mutation and is very common. There is a rare form of lactose intolerance present at birth known as congenital lactose deficiency, which is caused by a genetic mutation.
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CSID is caused by a mutation of a gene in chromosome 3, producing a deficiency of sucrase enzymatic activity, making the body unable to digest sucrose.
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Lactose intolerance is considered very common, excluding the rare congenital lactose deficiency.
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CSID is a rare disease.
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Onset can occur at any age, excluding the rare congenital lactose deficiency, which is present at birth.
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CSID is congenital, or present at birth.
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