How Does CSID Differ from Lactose Intolerance?

CSID/genetic sucrase deficiency is similar to lactose intolerance, a well-known carbohydrate malabsorption condition. The table below compares CSID to lactose intolerance.

 

LACTOSE INTOLERANCECSID
Lactose intolerance is the small intestine's inability to digest lactose due to a lack of the enzyme lactase.CSID is the small intestine's inability to digest sucrose due to a lack of the enzyme sucrase.
Lactose is a type of carbohydrate found in milk and other dairy products.Sucrose is a type of carbohydrate, commonly referred to as table sugar, and is naturally found in many fruits and vegetables. Sucrose is a common additive to many processed foods.
Ingestion of milk sugars causes gastrointestinal symptoms similar to those in CSID.Ingestion of sucrose causes gastrointestinal symptoms, most commonly diarrhea, bloating, abdominal pain, or gas.
Lactose intolerance is typically not caused by a genetic mutation and is very common. There is a rare form of lactose intolerance present at birth known as congenital lactose deficiency which is caused by a genetic mutation.CSID is caused by a mutation of a gene in chromosome 3 producing a lack of the sucrase enzymatic activity, making the body unable to digest sucrose.
Lactose intolerance is considered to be very common, excluding the rare congenital lactose deficiency.CSID is considered to be very rare.
Onset can occur at any age, excluding the rare congenital lactose deficiency.CSID is congenital, or present at birth.